Antihypertensive drugs individualizing therapy

When any antihypertensive drug is given, postural or orthostatic hypotension may be seen in some patients, especially early in therapy. Postural hypotension is the occurrence of dizziness and light-headedness when the individual rises suddenly from a lying or sitting position. Orthostatic hypotension occurs when the... 

This study also had two main limitations first, most of the trials were small, which precluded definitive conclusions about the effects of individual NSAIDs or individual antihypertensive drug classes secondly, in most studies, therapy was short term and the patients were relatively young, making generalization of the results difficult, as NSAIDs are most often prescribed long term and for elderly people. 

While the main goal of antihypertensive therapy is to achieve target blood pressures, the selection of agents for an individual should also account for certain special considerations and a patient s comorbidities. Specific antihypertensive therapy is warranted for certain patients with comorbid conditions that may elevate their level of risk for cardiovascular disease. Clinical conditions for which there is compelling evidence supporting one or more classes of drug therapy include 2... 

Second and subsequent weeks Increase dosage to 50 mg 4 times daily. Maintenance Adjust dosage to lowest effective level. Twice daily dosage may be adequate. In a few resistant patients, up to 300 mg/day may be required for a significant antihypertensive effect. In such cases, consider a lower dosage of hydralazine combined with a thiazide or reserpine or a beta-blocker. However, when combining therapy, individual titration is essential to ensure the lowest possible therapeutic dose of each drug. 

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