Antihistamines cardiovascular adverse effects

Although anticholinergic (drying) effects contribute to efficacy, adverse effects such as dry mouth, difficulty in voiding urine, constipation, and potential cardiovascular effects may occur (see Table 79-1). Antihistamines should be used with caution in patients predisposed to urinary retention and in those with increased intraocular pressure, hyperthyroidism, and cardiovascular disease. 

Newer, safer drugs that are selective inhibitors of sero-tonin reuptake [e.g., fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil)] have no or minimal antimuscarinic, antihistaminic, or adverse cardiovascular effects. They are now the drugs of choice for treatment of depressive disorders. 

What adverse cardiovascular effects can be seen with antihistamine therapy ... 

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