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Intramolecular oxidative coupling of phenols (6, 516). A biomimetic synthesis of natural silybin (3), an interesting antihepatotoxic agent, involves oxidation of a mixture of optically active 1 and coniferyl alcohol (2) with AgO in a benzene-acetone mixture at 55°. This reaction affords a mixture of silybin (3) and isosilybin (4) in 78% yield. The products 3 and 4 are diastereomeric mixtures at C2 and Cs- relative to C2 and... [Pg.211]

See other pages where Antihepatotoxic agents silybin is mentioned: [Pg.433] [Pg.433] [Pg.255] [Pg.895] [Pg.152]

See also in sourсe #XX -- [ Pg.26 , Pg.255 ]

See also in sourсe #XX -- [ Pg.255 ]