Antigens demyelination diseases

Zehnbier SP, Brisebois M, Tran E, Owens T, Fournier S (2003) Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease. FASEBJ 17 1910-1912. 

MBP or MBP peptides are very commonly used to induce EAE. The MBP-induced disease in some strains of mice is often monophasic with inflammation and no demyelination. The mice recover completely after a single episode of a short and acute disease and become resistant to reinduction of EAE. Therefore, a combination of antigens involving proteins or peptides (Kuerten et al., 2006) or sphingoglycolipids (Raine et al., 1981) are often used to induce demyelination. 

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