Antifungal isocoumarin

Methoxymellein, an antifungal isocoumarin[Fig. (1)], was first isolated as the metabolite that is responsible for the bitter taste in cold-stored... 

The isocoumarin, oosponol (43), which is produced by Basidiomycete, Gloeophyllum sepiarium, possesses marked antifungal activity against Candida albicans and Trichophyton asteroides [134]. In addition, many examples of synthetic isocoumarins have been reported to possess antifungal activity [135,136,137]. 

Isocoumarins are an important class of heterocyclic scaffolds that exhibit a wide range of biological activities, such as antifungal, antibacterial, and antidiabetic effects. In 2012, several copper-catalyzed procedures for the synthesis of isocoumarins were developed. Xi and co-workers developed an... 

Isocoumarin (2) is the structural isomer of coumarin some isocumarin derivatives show antifungal, antimicrobial, and phytotoxic activities [44]. 

Isocoumarins display a very wide range of biological activities. Many fungal isocoumarins exhibit antifungal activity (304), particularly oospolactone (23) (201), cladosporin (86) (253) and 6-methoxymellein (53) (85). 

Nozawa, K., M. Yamada, Y. Tsuda, K. Kawai, and S. Nakajima Synthesis and Antifungal Activity of 3-Substituted Isocoumarins. Chem. Pharm. Bull. (Japan) 29, 2491 (1981). 

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