Antiepileptics therapeutic range

Theoretical depiction of phenytoin concentrations achieved following various doses of the antiepileptic phenytoin. Shaded area indicates the therapeutic range of phenytoin concentrations below 10 (xg/mL, results in subtherapeutic effect above 20 (xg/mL, results in toxicity. Within the therapeutic range, a relatively small increase in dose results in a greater than proportional increase in concentration, suggesting nonlinear pharmacokinetics. 

At the therapeutic range for antiepileptic medications, CMIA requires only a few microlitres of serum from the patient for cortisol the assay of serum from a patient suffering from hyperandrogeny was performed with 50 pL of serum. Where comparison was possible, it was shown that the sensitivity of the CMIA method is identical to that of a RIA assay using a tracer labeled with " C. 

The drugs used as antiepileptics are a disparate group, and their interactions need to be considered individually. Carbamazepine and phenytoin have established ranges of therapeutic plasma levels and these are typically fairly narrow. Modest changes in plasma levels may therefore be clinically important. 

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