Antiepileptic drugs hypersensitivity syndrome

Schlienger RG, Shear NH. Antiepileptic drug hypersensitivity syndrome. Epilepsia 1998 39(Suppl 7) S3-7. 

Eland lA, Dofferhoff AS, Vink R, Zondervan PE, Strieker BH. Cohtis may be part of the antiepileptic drug hypersensitivity syndrome. Epilepsia 1999 40(12) 1780-3. 

Scheuerman O, Nofech-Moses Y, Rachmel A, A ikenazi S. Successful treatment of antiepileptic drug hypersensitivity syndrome with intravenous immune globulin. Pediatrics (2001) 107, E14. 

Hematologic Agranulocytosis has been observed as an unexpected progression from a phenytoin-associated antiepileptic drug hypersensitivity syndrome [248 ]. 

Patients with Stevens—Johnson syndrome or toxic epidermal necrolysis due to antiepileptic drugs have been compared with patients with antiepileptic drug-related hypersensitivity syndrome the results are shown in Table 1 [79 ]. The authors concluded that these cutaneous syndromes may share some clinical and laboratory features. 

Hypersensitivity to barbiturates can result in a life-threatening syndrome called the Drug, Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome with a mortality of 10%. In persons developing hypersensitivity to barbiturates, there is a potential of cross-sensitivity with other aromatic antiepileptics, such as phenytoin and carbamazepine. 

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