Antiemetics systematic reviews

Tramer MR, Walder B. Efficacy and adverse effects of prophylactic antiemetics during patient-controUed analgesia therapy a quantitative systematic review. Anesth Analg 1999 88(6) 1354-61. 

Systematic reviews Pethidine has been compared with dihydroergotamine, antiemetics, and ketorolac in acute migraine [154 ]. Pethidine caused more dizziness and sedation and was less efficacious than the antiemetics, although they were associated with akathisia. There were no... 

Nervous System A systematic review of low-dose use of droperidol as an antiemetic from 25 trials (2957 patients) reported extrapyramidal side effects, increased restlessness and decreased headache [143 ]. A study of use in 144 children at doses of 10 ng/kg reported sedation as the only side effect in 27% [144 ]. The use of low-dose droperidol for the treatment of headaches in the emergency room in 73 patients was associated with two cases of extrapyramidal reaction (restlessness/anxiousness and dystonia) [145 ]. Three of 589 patients experienced extrapyramidal reactions with droperidol infusion for nausea and vomiting [146 ]. Adverse effects occurring in 49 elderly patients treated with droperidol for agitation include hypotension (2), oversedation (2) and hypotension/oversedation (1) [147 ]. A case of an extrapyramidal reaction ataxia/dyskinesia) is reported in a female undergoing laparoscopic cholecystectomy [148 ]. 

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