Antidiarrhoeal agent

This can be controlled with the co-administration of standard antidiarrhoeal agents such as loperamide. All patients on FOLFOX chemotherapy (or any 5-fluorouracil-containing regimen) should be co-prescribed an antidiarrhoeal medication to use on an as required basis. The onset of diarrhoea should also indicate to the patient that they must increase their fluid intake to prevent dehydration. Patients must be warned that if the diarrhoea is not controlled (for example, within 48 hours of onset) then dehydration is a danger and they should be advised to contact their treating hospital or GP for advice. Severe manifestations may have to be managed by delay and/or dose modification of the patient s next cycle of chemotherapy. 

Tra 5-2,5-dimethyl-3-pyrroline (379) was alkylated with methyl bromoace-tate to give (380) which with guanidine gave rolgamidine (381) Scheme 5.87.) [512]. This is an antidiarrhoeal agent. 

Antidiarrhoeal agents—small quantities absorb excess water in the colon. Tannins if present have a binding effect, e.g. slippery elm powder... 

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