Antidepressants serotonin-mediated neurotransmission

In the early 1970s, evidence of the role of serotonin (5-hydroxytryptamine or 5-HT) in depression began to emerge and the hypothesis that enhancing 5-HT neurotransmission would be a viable mechanism to mediate antidepressant response was put forward. In 1968, Arvid Carlsson (Goteborg, Sweden) had already found that, when an electrical impulse passed from one neuron to another, serotonin was released into the space between the neurons - the synapse - to help the message to be transmitted and its... 

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