Antidepressants interactions

Giros B., Wang Y., Sutter S., McLeskey S., Pfil C., Caron M. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine... 

Paczkowski FA, Sharpe lA, Dutertre S, Lewis RJ. (2007) X-Conotoxin and tricyclic antidepressant interactions at the norepinephrine iransporter define a new transporter model. J Biol Chem 282 17837-17844. 

Bergstrom RF, Peyton AL, Lemberger L. Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction. Clin Pharmacol Ther 1992 51 239-248. 

Bergstromm, R. F., Peyton, A. L., Lemberger, L. (1992). Quantification and mechanism of fluoxetine and tricyclic antidepressant interaction. Clinical Pharmacology and Therapeutics, 51, 239-248. 

The large number of drugs with which tricyclic antidepressants interact are summarized in Table 3 those of major concern are discussed in more detail below. 

Graham PM, Potter JM, Paterson J. Combination monoamine oxidase inhibitor/tricyclic antidepressants interaction. Lancet 1982 2(8295) 440. 

In therapeutic doses, the tricyclic antidepressants also cause a variety of less serious unwanted side effects. Many of these are associated with the ability of many of these drugs to act as antagonists at various monoamine receptors (see Table 8.6 below). Antidepressants interact with a large number of neurotransmitter receptors. Some of the targets listed in Table 8.6 represent multiple subtype for example, 5-HT2 is in fact a composite of effects of 5-HT , 5-Hr , and S-HTgc- (For a... 

Patients with coexisting cardiovascular and pulmonary conditions (e.g., ARDS, pulmonary infection, pulmonary aspiration) may be more susceptible to the toxic effects or complications of tricyclic antidepressant poisoning. The influence of chronic exposure to tricyclic antidepressants on the risks of an acute overdose is unclear. Tricyclic antidepressants interact with other central nervous system depressant drugs, which together may lead to increased central nervous system and respiratory depression. 

Jurima-Romet M, Wright M, Neigh S. Terfenadine-antidepressant interactions an in vitro inhibition study using human liver microsomes. BrJ Clin Pharmacol (1998) 45, 318-21. 

Graham PM, Potter Paterson JW. Combinaticn monoamine oxidase inhibitor/tricyclic antidepressant interaction. Lancet (1982) ii, 440. 

Vandel S, Bertschy G, Allers G. Fluvoxamine tricyclic antidepressant interaction. Thenqrie (1990)45,21. 

Bertschy G, Vandel S, Vandel B, Allers G, Vomat R. Fluvo amine-tiicycIic antidepressant interaction An accidental finding. EurJ Clin Pharmacol (1991) 40,119-120. 

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