Antidepressants African Americans

Wagner etal. (1998) investigated the ethnic differences in antidepressant response to fluoxetine or placebo in 118 depressed, predominantly male, HIVpositive patients (White n = 79, Hispanic n = 17, African American n = 22). Nine Hispanic subjects (53%) dropped out of treatment making the results difficult to interpret. Among completers in the placebo arm, 80% (four out of five) of Hispanic subjects were responders as compared to 36% of African American subjects and 43% of White subjects. 

Research in psychopharmacology has shown that ethnicity must be considered in psychiatry as well (Lawson, 1986 Pi 8c Simpson, 2005). Early clinical trials with antipsychotic and antidepressant medications showed that ethnic minorities may respond when given the same doses as Caucasians, and may have more side effects (Lawson, 1986 Lawson, 1990). However, dosing cannot be used as a measure of appropriate pharmacotherapy because an extensive literature has shown that African Americans often receive higher doses of antipsychotics despite evidence of more side effects. 

CYP2C19 Benzodiazepines diazepam Antidepressants imipramine, amitriptyline, clomipramine, citalopram Others propranolol, hexobarbital, mephobarbital, proguanil, omeprazole, S-mephenytoin 2 no activity 23%-39% in Asians 13% in Caucasians 25% in African Americans 3 no activity 6%-10% in Asians 0% in others... 

The results of our study focusing on antidepressant dosing at the time of discharge tend to corroborate previous evidence that African American patients need lower doses of TCAs than do Caucasian patients. Results are more equivocal with respect to our study of African American and Caucasian patients taking SSRIs. However, when weight is taken into consideration, it is found that African Americans might need lower doses of SSRIs compared with Caucasians. 

Adam see Ecstasy Adderall see Amphetamines Adipex-P see Diet pills Aerosol propellants see Inhalants African black see Marijuana African salad see Catha etlulis African tea see Catha etlulis Afterburner bromo see 2C-B Ah-pen-yen see Opium Air blast see Inhalants Alfenta see Fentanyl Allium sativum see Herbal drugs Alprazolam see Benzodiazepine Alurate see Barbiturates Amber see Herbal drugs Ambien see Tranquilizers American ephedra see Ephedra Amiloride see Diuretics Amitriptyline see Antidepressants Amobarbital see Barbiturates Amoeba see PCP (phencyclidine) Amoxapine see Antidepressants AMT see Dimethyltryptamine (DMT) Amy see Amyl nitrite Amyl nitrate see Amyl nitrite... 

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