Anticonvulsant mechanisms, role

Role of Calcium and Sodium Antigonism in Anticonvulsant Mechanisms... 

The prostaglandins in the nervous system have been implicated to have physiological roles in temperature regulation, brain circulation and possibly in neuromodulation [201], The administration of prostaglandins of the E-series intraventricularly has been shown to have sedative effects in rodents and chickens [216]. In the mouse, a dose-dependent inhibition of picotoxin and pentahazol induced convulsion was observed [217,218]. In the cat prostaglandins inhibited penicillin induced seizures [219]. The mechanism of the anticonvulsive action of PGE compounds is not clear. 

In the last years there have been increasing interest in the role of taurine in the central nervous system (CNS), because of its possible association with the mechanisms regulating nervous excitability . After the finding of the generalized anticonvulsant action of taurine ", as well as of its effects on human epilepsies... 

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