Anticoagulants action, mode

Mode of action. Heparin depends for its anticoagulant action on the presence in plasma of a single chain glycoprotein, antithrombin (formerly antithrombin III), a naturally-occurring inhibitor of... 

Because rodent populations world-wide were becoming resistant to the widely used Warfarin-type anticoagulant poisons, a search was initiated to find a rodenticide with a different mode of action one that would be effective against these resistant rodents. This search led to the discovery of the toxic nature of a family of diphenyl amines which act as uncouplers of oxidative phosphorylation. A structure-activity relationship (SAR) study was undertaken to choose a derivative that would be both poisonous to rodents but still readily consumed by them. This approach led to the discovery of bromethalin,... 

Bromethalin is a unique, highly potent rodenticide which satisfies most of the criteria of an ideal rodenticide. It offers a distinct advantage over currently used acute and anticoagulant rodenticides because of its unique mode of action. Bromethalin... 

Heparin is clearly an extraordinarily complex substance with many highly polar groups, and its mode of action as an anticoagulant is not clear. At present, because of increases in the use of artificial kidney machines, heparin is in rather short supply. 

Though the mode of action of bromethalin [61] is not known, it has been determined that it is not an anticoagulant as flocoumafen is. The presence of four bulky groups ortho to the tertiary nitrogen makes its synthesis challenging. Bromethalin synthesis involves introducing one or more of the ortho bulky groups after the formation of diphenylamine (Fig. 16) [62],... 

The mode of action of the coumarin anticoagulants involves blocking the regeneration of reduced vitamin K and induces a state of functional vitamin K deficiency, thus interfering with the blood-clotting mechanism (178). 

Coagulation system the mode of action of drugs chat promote coagulation and that prevent it (anticoagulants) and their uses... 

Vitamin K plays a role in the blood[Pg.773]

Nagashima H. Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and argatroban. J Biol Chem 2002 277 50439-50449. 

Nylander S, Mattsson C. Thrombin-induced platelet activation and its inhibition by anticoagulants with different modes of action. Blood Coagul Fibrinolysis 2003 14 159-167. 

ANTICOAGULANT ACTIVITY Structure-activity relationships Mode of action Toxicity... 

Another theory was offered to explain the mode of action of these compounds when it was noted that dicoumarol is a potent uncoupling agent of oxidative phosphorylation [363]. The antibacterial action of the 3-acetyl-4-hydroxycoumarin may be associated with its uncoupling action [364, 365]. Similarly, a relationship has been suggested between the anticoagulant activity of dicoumarol and related compounds and their uncoupling activity [366]. 

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