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Metabolism anticoagulant rodenticides

Anticoagulant therapy Metabolism Rodenticidal action Antiatherosclerotic action... [Pg.86]

Racemic warfarin (65), a vitamin K antagonist, has been used for decades both as an oral anticoagulant in man and as a rodenticide. The metabolism of this drug has been found to be substrate-enantioselective 9S-warfarin is considered as more active than the 9R-antipode. In mammalian systems, warfarin undergoes a stereoselective reduction of the ketonic side chain [176,177], affording mainly the 9R,llS-alcohol (71), but the major biotransformation route involves substrate-enantioselective aromatic hydroxylations at 4 -, 6-, 7- or 8-positions... [Pg.201]

See other pages where Metabolism anticoagulant rodenticides is mentioned: [Pg.221]    [Pg.134]    [Pg.260]    [Pg.5079]    [Pg.543]    [Pg.224]   
See also in sourсe #XX -- [ Pg.221 ]



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