Anticoagulant drugs, chiral

A D Hulst, N Verbecke. Separation of enantiomers of coumarinic anticoagulant drugs by capillary electrophoresis using maltodextrins as chiral modifiers. Chirality 6 225-229, 1994. 

The important anticoagulant drug warfarin is chiral and is administered cimically as the racemic mixture. Significant pharmacodynamic and pharmacokinetic differences between the enantiomers have generated considerable interest in the stereochemical aspects of this drug (145),... 

Other chiral coumarin anticoagulant drugs have been determined to exhibit higher enantioselectivity in binding to site I of HSA than warfarin. 

An additional point is that both mobility and affinity effects must be considered and a conclusion about a favorable affinity pattern for an enhancement of a chiral separation may be drawn depending on the effect of both chiral selectors on the mobility of the analyte [12, 47], Some of these points are illustrated in [48] using the anticoagulant drug warfarin as a chiral analyte. 

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