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Anticancer agents/drugs/pharmaceutics

Pnor to 1975, discussions of fluonnatcd pharmaceuticals focused mainly on anti-mflammatory steroids, antipsychotic phenothiazines, and 5-fluorouraciI and Its derivatives as anticancer agents [/ 2] Dunng the past 25 years, and especially in the last decade, tluonnated dmgs have been marketed for the treatment of a wide variety of diseases This section will focus on those presently marketed drugs where the presence of fluonne has produced significant therapeuhc advantages... [Pg.1119]

One of the potential uses of any molecular container compound is in the formulation of active pharmaceutical agents. Accordingly, the groups of Kim [29] and Day [30] have demonstrated the ability of CB[7] and CB[8] to modify the properties of Pt-based anticancer agents (Scheme 4.11). For example, Kim s group reported that CB[7] forms a 1 1 complex with oxaliplatin (CB[7] 29). They found that encapsulation of the drug... [Pg.123]

Nuijen B, Bouma M, Talsma H, Manada C, Jimeno JM, Lopez-Lazaro L, Bult A, and Beijnen JH. Development of a Lyophilized Parenteral Pharmaceutical Formulation of the Investigational Polypeptide Marine Anticancer Agent Kahalalide F. Drug Dev Ind Pharm 2001 27(8) 767-780. [Pg.355]

Vries JDJ, Flora KP, Bult A, Beijnen JH. Pharmaceutical Development of (Investigational) Anticancer Agents for Parenteral Use - A Review. Drug Dev IndPharm 1996 22 475-494. [Pg.92]

Nuijen B, Rodrigues-Campos IM, Noain CP, et al. (2001) HPLC-UV method development and impurity profiling of the marine anticancer agent aplidine in raw drug substance and pharmaceutical dosage form. Journal of Liquid Chromatography and Related Technologies 24 3119-3139. [Pg.2729]


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See also in sourсe #XX -- [ Pg.42 , Pg.105 , Pg.296 , Pg.474 , Pg.639 ]




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