Anticancer Activities of the P Lactams

Several of these p-lactams were tested using nine human cancer cell lines with cisplatin and diamide lb as controls. The results are shown in Table 1. 

The stmcture activity study revealed that, regardless of the configuration of the p-lactams, neither naphthalene (22) and anthracene (24) nor pyrene derivatives (28) 

All the In vitro cytotoxicity assays were performed using MTT assay 

The anticancer activity of our racemic p-lactams has prompted us to devise method for the preparation of the optically active analogues. It is known that an optically active isomer of a racemic compound has better and much selective biological 

Cycloaddition of the acid 62 with imine 29a was performed using imine in the presence of Ai-methyl-2-chloropyridiniumiodide (53) and triethylamine. NMR analyses of the crude reaction mixture showed the presence of two diasteromeric trans (3-lactams 63 and 64 in 60 40 ratios. The diaseteromeric O-glycosides after 

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