Antibodies to polynucleotides

Studies of the specificities of experimentally induced antipolynucleotide antibodies have yielded some information on the antigenic determinants which could exist in a molecule of nucleic acid. Like the antibodies to proteins or synthetic polypeptides, antibodies to polynucleotides can be directed against different antigenic determinants derived from sequential regions as well as conformational factors in the molecule. Since antibodies in which the specificity is associated with the heterocyclic bases are obtained by use of single-stranded polynucleotides or certain components of nucleic acids it is thus evident that the bases themselves can be included among the antigenic determinants of polynucleotides. 

Lacour, F., Michelson, A. M., Nahon, E. Specific antibodies to polynucleotide complexes and their reaction with nucleic acids importance of the secondary structure of the antigen. In Nucleic acids in immunology, ed. by Plescia O. J. and Braun W., p. 32-46. Berlin—Heidelberg—New York Springer 1968. 

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