Antibodies inhibition patterns

Fig. (13A). Inhibition patterns for anti-S. pyogenes antibodies. Ab=antibody, I, =Ab + GlcNAc, l2=Ab + Rha. Wells 106 and other outside wells contain decreasing amounts (20-1 pg) of antigen (group A polysaccharide).

For three other myeloma proteins having anti-(l — 6)-a-D-glucopyranan specificity (W 3129, W 3434, and QUPC 52), the authors found a somewhat different pattern of cross-reactivity.63 The reaction of W 3129 with its anti-idiotypic antibody was not totally inhibitable by even high concentrations of W 3434 protein, and not at all by protein QUPC 52. Thus, proteins W 3129 and W 3434 share some determinants, but are clearly different from each other and from QUPC 52. 

While this pattern of biochemistry does not exclude transient relapse of Graves hyperthyroidism (despite the finding of negative TSH receptor antibodies), or a transient thyroiditis, the authors speculated that indinavir (prescribed in this patient together with stavudine and lamivudine) had inhibited the glucuronidation of thyroxine and hence caused a rise in serum thyroid hormone concentrations. 

N-CAM the prototype adhesion molecule of the immunoglobulin superfamily N-CAM was first identified in chick embryo nervous tissue using an antibody that specifically inhibited the re-aggregation of dissociated nerve cells [56,57]. Subsequently, the antibodies were shown to alter the normal patterns of differentiation in the chick embryo, to inhibit the bundling of neurites into nerve fascicules and to prevent the... 

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