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Antibodies hypervariable regions

Infliximab is a chimeric monoclonal antibody targeted against TNF-a. It consists of a human IgGi Fc heavy chain and partial K-Iight chain fused to a murine hypervariable region. Infliximab binds to both soluble and transmembrane forms of TNF-a and inhibits their ability to bind to TNF receptors. It does not inhibit TNF- 3, which binds to the same receptors as TNF-a. Infliximab is administered intravenously, usually at 4- to 8-week intervals. [Pg.435]

Recombinant technology can be used to produce novel antibody constructs. The potential to produce antibody fragments consisting only of variable regions, or in extreme case of single chain constructs on which the hypervariable regions are assembled has been explored. Protein engineering can also be used to produce... [Pg.78]

See other pages where Antibodies hypervariable regions is mentioned: [Pg.211]    [Pg.301]    [Pg.302]    [Pg.311]    [Pg.317]    [Pg.320]    [Pg.601]    [Pg.1179]    [Pg.1179]    [Pg.591]    [Pg.592]    [Pg.276]    [Pg.85]    [Pg.94]    [Pg.826]    [Pg.140]    [Pg.86]    [Pg.382]    [Pg.102]    [Pg.134]    [Pg.254]    [Pg.254]    [Pg.185]    [Pg.188]    [Pg.201]    [Pg.384]    [Pg.268]    [Pg.302]    [Pg.418]    [Pg.451]    [Pg.273]    [Pg.210]    [Pg.1838]    [Pg.1838]    [Pg.1860]    [Pg.457]    [Pg.833]    [Pg.846]    [Pg.350]    [Pg.102]    [Pg.516]    [Pg.115]    [Pg.254]    [Pg.254]    [Pg.295]    [Pg.296]    [Pg.227]    [Pg.237]    [Pg.246]   
See also in sourсe #XX -- [ Pg.102 ]

See also in sourсe #XX -- [ Pg.126 ]



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Antibodies regions

Hypervariability

Hypervariable regions

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