Antibiotics synth

Annulenes, bridged, 38,123-124, 333-334 Anthracene Diels-Alder addn. to, 93 —, 9-(chloromethyl)- mutagen, 341-342 Antibiotics synth., 310-329 (See also Griseo-fulvins, 74, 86)... 

C4H,C1N03 M 153.565 Prod, by Streptomyces sp. OH-5093. Herbicidal antimetabolite also exhibiting antifungal activity. Component of Syringostatin A, S-01629 and Syringomycin, S-01627. Intermed. in j -lactam antibiotic synth. Powder. Mp 142-143°. [a] -81 (c, 0.43 in H2O). [132958-66-8]... 

D. Bouzard, Recent Prog. Chem. Synth. Antibiot., 249 (1990). 

Nagata, W. "Synthetic Aspects of 1-Oxacephem Antibiotics , in Curr. Trends Org. Synth., Proc. Int. Conf, 4th, Tokyo, 22.-27.8.1982 Ed. by H. Nozaki Pergamon Press 1983. 

ACIE ACR ACS, Ser. B Ag.BC AJC Ann BCS, Jpn Ber Bioorg. Chem. BSC, Belg Chem. Ind. CJC CL CPB CSR HCA Het J. Antihiot JACS JCS JCS, CC JCS, PI JHC JMC JOC P AC PCS PJPS PNAS Synth Synth. Comm. Tet TL Angew. Chem. Int. Ed. Acct. of Chem. Res. Acta Chem. Scandinavica, Series B Agri. Biol. Chem. Aust. J. Chem. Annalen Chemie Bull. Chem. Soc., Japan Chem. Ber. Bioorganic Chemistry Bull. Soc. Chim., Belg. Chem. and Industry Canadian J. Chem. Chem. Lett. Chem. Pharm. Bull., Japan Chem. Soc. Review Helv. Chim. Acta Heterocycles J. Antibiotics J. Am. Chem. Soc. J. Chem. Soc., London J. Chem. Soc., Chem. Commun. J. Chem. Soc., Perkin Trans. I J. Heterocyclic Chem. J. Med. Chem. J. Org. Chem. Pure and Appl. Chem. Proc. Chem. Soc., London Proc. Japan Pharm. Soc. Proc. Natl. Acad. Sci., USA Synthesis Synthetic Commun. Tetrahedron Tetrahedron Lett. 

Cefotaxime (Claforan) [Antibiotic/Cephalosporin-3rd Generation] Uses Rx Infxns of resp tract, skin, bone, urinary tract, meningitis, s is Action 3rd-gen cephalosporin X cell wall synth Dose Adults. 1-2 g IV... 

Cephradine (Velosef) [Antibiotic/Cephalosporin-1 st Generation] Uses Resp, GU, GI, skin, soft tissue, bone, joint Infxns Action Ist-gen cephalosporin X cell wall synth Dose Adults. 250-500 mg q6-12h... 

Ertapenem (Invanz) [Anti infective/Carbapenem] Uses Complicated intra-abd, acute pelvic, skin Infxns, pyelonepluitis, community-acquired pneumonia Action A carbapenem p-lactam antibiotic, cell wall synth Dose Adults. 1 g IM/IV daily 500 mg/d in CrCl <30 mL/min Peds. 3 mo-12 y ... 

Fosfomycin (Monurol) [Antibiotic] Uses Uncomplicated UTl Action -1- CeU w l synth Dose 3 g PO in 90-120 mL of H2O single dose X in renal impair Caution [B, ] -t Absorption w/ antacids/Ca salts Contra Component sensitivity Disp Granules SE HA, GI upset Interactions X Effects W/ antacids, metoclopramide EMS Monitor ECG and BP for signs of hypovolemia and electrolyte disturbances d/t D OD May cause impaired coordination, hearing loss and bitt taste in mouth symptomatic and supportive... 

Mercaptopurine [6-MP] (Purinethol) [Antineoplastic/ Antimeta lite] Uses Acute leukemias, 2nd-line Rx of CML NHL, maint ALL in children, immunosuppressant w/ autoimmune Dzs (Crohn Dz) Action Antimetabolite, mimics hypoxanthine Dose Adults. 80-100 mg/mVd or 2.5-5 mg/kg/d maint 1.5-2.5 mg/kg/d Peds. Per protocol X w/ renal/hepatic insuff on empty stomach Caution [D, ] Contra Severe hepatic Dz, BM suppression, PRG Disp Tabs SE Mild hematotox, mucositis, stomatitis, D rash, fever, eosinophilia, jaundice. Hep Interactions T Effects W/ allopurinol T risk of BM suppression W/ trimethoprim-sulfamethoxazole X effects OF warfarin EMS May falsely T glucose OD May cause NA and liver necrosis symptomatic and supportive Meropenem (Merrem) [Antibiotic/Carbapenem] Uses lntra-abd Infxns, bacterial meningitis Action Carbapenem X cell wall synth, a [3-lactam Dose Adults. 1 to 2 g IV q8h Peds. >3 mo, <50 kg 10-40 mg/kg IV q 8h in renal insuff Caution [B, ] Contra [3-Lactam sensitivity Disp Inj 500 mg, 1 g SE Less Sz potential than imipenem D, thrombocytopenia Interactions T Effects W/ probenecid EMS Monitor for signs of electrolyte disturbances and... 

Trimethoprim (TMP)-Sulfamethmazole (SMX) [Co-Trimoxazole] (Bactrim, Septra) [Antibiotic/Folate Antagonist] Uses un Rx prophylaxis, otitis media, sinusitis, bronchitis Action SMX T synth of dihydro-folic acid TMP T dihydrofolate reductase to impair protein synth Dose Adul. 1 DS tab PO bid or 5-20 mg/kg/24 h (based on TMP) IV in 3-4 doses P. jiroveci ... 

Ulcerative colitis Action 5-ASA derivative, anti-inflammatory, 1 leukotiiene synth Dose 2.25 g (3 caps) tid x 8-12 wk Caution [B, ] Severe renal/hepatic failure Contra Mesalamine or salicylates hypersensitivity Disp Caps SE Dizziness, HA, N, agranulocytosis, pancytopenia, renal impair, allergic Rxns Interactions Oral antibiotics may interfere W/ mesalamine release in the colon EMS Allergic Rxn can occur if pt is allergic to ASA or other salicylates OD Not reported but may cause V, tinnitus, confusion and vertigo symptomatic and supportive... 

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