Antibiotics and immunosuppression

Hydroxy-6-methoxy-7-methyl-3-oxo-l,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic (mycophenolic) acid as antibiotic and immunosuppressant 00CRV3801. 

Many pharmaceutically important natural products, including antibiotics and immunosuppressants, are based on cyclic peptides. Therefore, the ability to synthesize backbone cyclic peptides using EPL or protein transsplicing... 

Filamentous soil bacteria, including the strains belonging to the genus Streptomyces, have a complex morphological differential and are weU known for their abihty to produce an enormous variety of bioactive secondary metabolites, such as antibiotics and immunosuppressant drags. The entire nucleotide sequences of the Streptomyces genomes of Streptomyces coelicolor [1] and S. avermitilis [7] have... 

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