Antibacterials aminoglycosides, synthesis

Other key classes of antibacterials include the tetracyclines (Aureomycin, Terramycin), macrolides (erythromycin, Zithromax, Biaxin), and aminoglycosides (streptomycin, amikacin, neomycin). These antibacterials are protein synthesis inhibitors. 

Aminoglycoside a structurally complex antibacterial that works as bacterial protein synthesis inhibitor. 

Mechanism of Action An aminoglycoside antibacterial that irreversibly binds to protein on bacterial ribosomes. Therapeutic Effect Interferes with protein synthesis of susceptible microorganisms. 

Mechanism of Action An aminoglycoside antibacterial that binds to bacterial microorganisms. Therapeutic Effect Interferes with bacterial protein synthesis. Pharmacokinetics Poorly absorbed from the GI tract following PO administration. Protein binding Low. Primarily eliminated unchanged in the feces minimal excretion in urine. Removed by hemodialysis. Half-life 3 hr. 

Antibacterial drugs that affect bacterial protein synthesis include the aminoglycosides, tetracyclines, macrolides, and the single drug chloramphenicol. 

Antibacterial drugs that inhibit protein synthesis aminoglycosides, tetracyclines, macrolldes and chloramphenicol... 

Copyright (2005) from (Novel Method for the Synthesis of 3, 4-Dideoxygenated Pyranmycin and Kanamycin Compounds, and Studies of Their Antibacterial Activity against Aminoglycoside Resistant Bacteria) by (Cheng-Wei Tom Chang). Reproduced by permission of Taylor Francis Group. LLC., http//www.taylorandfrancis.com. 

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