Antiandrogens long-term effects

Because ketoconazole has antiandrogenic properties, it is particularly suitable for women, in whom it has few effects on menstruation and does not cause hirsutism. In men, however, long-term inhibition of androgen production can be disruptive, especially if it leads to gynecomastia and hypogonadism. Combination with ami-noglutethimide and metyrapone has been advocated in order to avoid these effects (SEDA-17, 323). 

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