Anti-self response

Ribas A, Camacho LH, Lopez-Berestein, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated... 

HSC and progenitor cells after radiation exposure have the self-renewal capacity needed for leukemia induction. This was shown at low, intermediate and high dose intervals. Cells in patients as compared to controls more often expressed anti-apoptotic protein Bcl-2 and less often demonstrated expression of Fas receptor (fig. 6-7). Cells in patients with low CD8-h counts were simultaneously Fas negative and Bcl-2 positive in 4 out of 19 studied patients. We assume that cells over-expressing anti-apoptotic protein Bcl-2 and demonstrating low Fas expression could lack apoptotic response to environmental factors. 

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