Anti-protozoal

Anti-neoplastic agents and immunosuppressants Anti-protozoal agents Anti-thyroid agents... 

ANTIHISTAMINES -terfenadine, hydroxyzine, mizolastine 8. ANTI-MALARIALS - artemether with lumefantrine, chloroquine, hydroxychloroquine, mefloquine 9. ANTI-PROTOZOALS - pentamidine isetionate 10. ANTIPSYCHOTICS-atypicals, phenothiazines, pimozide... 

Table 6.1 Common anti-protozoal drugs and their modes of action ...

For many of the commonly used anti-protozoal drugs the modes of action and mechanisms of selective toxicity are well understood, although for some the precise mechanism remains unclear. The most... 

Hudson, A. T., Randall, A. W., Fry, M., Ginger, C. D., Hill, B., Latter, V. S., McHardy, N., and Williams, R. B. (1985). Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. Parasitology 90(Pt 1), 45-55. 

Finally it should not remain unmentioned, that several STLs of other structural types have been found which contain a cyclic peroxide structure. The STL database (see Structural diversity of sesquiterpene lactones ) contains 88 entries with peroxide moieties of which 24 contain this structure as part of a ring system. Of these, 21 are not derived from seco-cadinane but belong to the guaianolide and xanthanolide series. It remains to be shown whether these compounds possess anti-protozoal activity in a similar way as the artemisininoids. 

C21H22O4, Mr 338.40, yellow needles, mp. 101 -102 °C. L. show anti-protozoal (antileishmanial, anti-malarial) activity. They are in preclinical development against malaria tropica. 

Third, these flavonoids reveal anti-protozoal, anti-inflammatory and antioxidant activities. Additionally, some isoflavones were also known to have their insecticidal, antifungal and antibacterial activities [43]. 

There are few reports which demonstrated the anti-protozoal activity of vegetable oils of Hypericum species (Moon, 2010 Zofou et al., 2011) based on the lipophilic components of the oil and its extract. A few studies have shown that long-chain fatty acids and P-sitosterol contributed to inhibit the protozoan organisms (Nweze et al., 2011). 

Anti-protozoal and anthelmintic examples, Biallylamicol ( Camoform ) ii,42)y which has proved a successful drug in amoebiasis, has chelating properties (Thompson et aL 1955 Dill et aLy 1957). 

SHINN, A.P., PICdN-CAMACHO, S., BRON, J.E., CONWAY, D., YOON, G.H., HUNTER, R., GUO, F.C. TAYLOR, N.G.H. (2011) The anti-protozoal activity of bronopol on the key fife-stages of Ichthyophthirius multifiliis Fouquet, 1876 (Ciliophora). Veterinary Parasitology. 

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