Anti-parasitic agents

Roundworms [ANTI PARASITIC AGENTS - ANTHELMINTICS] (Vol 3) veterinary drugs against [VETERINARY DRUGS] (Vol24)... 

The last decade has witnessed many promising developments in the field of medicinal chemistry, with organometallic compounds displaying anticancer and antimetastasis activity, and finding applications as antibiotics, antiviral and anti-parasitic agents [106-108]. 

Heinonen OP, Slone D, Shapiro S. Antimicrobial and anti-parasitic agents. In Heinonen OP, Slone D, Shapiro S,... 

A recent application is the synthesis of the anti-parasitic agent nafuredin 168 by Omura s group.34 Nafuredin has four alkenes in the side chain but disconnection near the middle of the molecule is strategically best. As with the Wittig, there is a choice where to put the sulfone and the aldehyde. The sulfone 169 can be easily made from an allylic alcohol. No doubt some of the functional groups in 169 will have to be protected. 

C. S. Ring, E. Sun, J. H. McKerrow, G. K. Lee, P. J. Rosenthal, I. D. Kuntz, F. E. Cohen. Structure-based inhibitor design by using protein models for the development of anti-parasitic agents. Proc. Natl. Acad. Sci. USA. 1993, 90, 3583-3587. 

Similarly, several medicines or potential medicines have been made that contain imidazole. Structurally, the molecules can be vastly different and can affect very imique disease states. For example, metronidazole is an antibiotic effective against anaerobic bacteria, and it also acts as an anti-parasitic agent. It is a relatively simple functionalized imidazole. Cipralisant is a potent H3 receptor antagonist H3 antagonists are believed to have potential therapy to aid in sleep, cognition, food intake, and memory. ... 

The dioxaspiro [5,5j undecane (45), a building block for the anti-parasitic agents milbemycin and avermectin, has been constructed in enantiomerically pure form from the dideoxy-sugar anhydride (46), which yields the phosphonium salt (47) on treatment with triphenyl-phosphonium tetrafluoroborate the ylide derived from (47) was... 

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