Anti-parasitic activity

Kubicek S, Jenuwein T (2004) A crack in histone lysine methylation. Cell 119 903-906 Kwon HJ, Kim JH, Kim M, Lee JK, Hwang WS, Kim DY (2003) Anti-parasitic activity of depudecin on Neospora caninum via the inhibition of histone deacetylases. Vet Parasitol 112 269-276 Lau OD, Kundu TK, Soccio RE, Ait-Si-Sli S, Khail EM, Vassilev A, Wolffe AP, Nakatani Y, Roeder RG, Cole PA (2000) HATs off Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell 5 589-595... 

Key words alkaloids, antimicrobial activity, anti-parasitic activity, biology, cytotoxicity, DNA, endogenous security mechanism, estrogenic effect, evolution, genes, haemoglobinization, immune system, inhibitor, locoism, narcotics, regulation, stimulator... 

Oxamniquine had good anti-parasite activity, especially versus South American strains, and that was relatively free of side effects. 

Both mebendazole and albendazole are used in the long-term treatment of infections and an overall success rate of 97% has been obtained. Albendazole may be the preferred drug as it is cheaper and easier to take than mebendazole (Reuter et al., 2000). Using nitazoxanide with albendazole in a murine model suggests that there may be improved anti-parasitic activity (Stettler et al., 2004). 

Stettler, M., Rossignol, F., Fink, R., Walker, M., Gottstein, B., Merli, M., TheuriMat, R., Thorman, W., Dricot, E., Segers, R. and Hemphill, A. (2004) Secondary and primary murine alveolar echinococcosis combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. International Journal for Parasitology 34, 615-624. 

Bua J, Ruiz AM, Potenza M, Eichera LE. In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 2004 14 4633-4637. 

Bach and Bartels used a Negishi cross-coupling reaction as a key step in their synthesis of eupomatenoid. Members of this class of compound have been shown to exhibit anti-parasitic activity against Leishmania and Trypanosoma cruzi. Reaction of 2,3,5-tribromobenzofuran with (3,4-dimethoxyphenyl)zinc(II) chloride gave the desired product selectively in 75% yield. 

Roussakki M, Hall B, Lima SC, da Silva AC, Wilkinson S, Detsi A. Synthesis and anti-parasitic activity of a novel quinolinone-chalcone series. Bioorg Med Chem Lett 2013 23(23) 6436-41. 

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