Anti neoplastic complexes

Messori L., Orioli R, Vullo D., Alessio E., lengo E., A spectroscopic study of the reaction of NAMl, a novel ruthenium(III)anti-neoplastic complex, with bovine serum albumin, Eur. J. Biochem., 267, 1206-1213, 2000. 

Many of the anti-neoplastic drugs currently available on the market specifically target the cancerous tumor and do not account for the overall heterogeneity of the disease. It is reasonable to assume that due to the complex make-up of a tumor, combined therapies may be necessary to treat the different cell types involved. One major hurdle to understanding tumor cells at the gene expression level is our limited ability to isolate pure populations of diseased cells. 

Saframycins. An antibiotic complex (to date 22 known components) from cultures of Streptomyces la-vendulae. The S. contain tetrahydroisoquinoline units dimerized via a piperazine structure. They have anti-neoplastic activity and are active against Gram-positive bacteria, e. g., S. B C2gH3,N308, Mr 537.57, orange prisms, mp. 108-109 C, [a]g,°-54.4° (CH3OH). 

S.J. Bannister, L.A. Stemson and A.J. Repta, Evaluation of reductive amperometric detection in the liquid chromatographic determination of anti-neoplastic platinum complexes, J. Chromatogr., 1983, 273, 301-318. 

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