Anti-malaria drugs

Reports have suggested that some alkaloids protect against TNF-a-dependent liver injury. Pretreatment with an anti-malaria drug quinine... 

Introduction three types of control Chemoselectivity simple examples and rules Chemoselectivity by Reactivity and Protection An anti-Malaria Drug... 

Chemoselectivity by Reactivity and Protection An anti-Malaria Drug... 

Levesque F, SeebergCT PH (2012) Continuous-flow synthesis of the anti-malaria drug artemisinin. Angew Chem Int Ed 51 1706-1709... 

A similar electrochemical based sensor was developed using nanocomposites of PANl, graphene and horse radish peroxidase on ITO glas [53]. This biosensor was able to measure very low concentration of anti-malaria drug in various pharmaceutical preparations and in different body fluids (urine, plasma and serum). 

The two Cinchona alkaloid selectors will be used to really get into a particular chiral recognition mechanism. Quinine is a natural alkaloid extracted from the bark of the South American Cinchona tree of the Rubiaceae family and used as an anti malaria drug (Fig. 6). Its 8 and 9 positions are, respectively, substituted in the S and R configuration. By chance, quinidine is the mirror image form of quinine, also found in the Cinchona bark with the 8R and 9S configuration. These two alkaloid enantiomers... 

Quinoline forms part of the structure of quinine, the malaria remedy found in cinchona bark and known since the time of the Incas. The quinoline in quinine has a 6-MeO substituent and a side chain attached to C4. In discussing the synthesis of quinolines, we will be particularly interested in this pattern. This is because the search for anti-malarial compounds continues and other quinolines with similar structures are among the available anti-malarial drugs. 

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