Anti-ischemic agents

EGb 761 might also directly scavenge peroxynitrites and inhibit lipid peroxidation because it has been reported both to block the cytotoxicity induced by peroxynitrites and inhibit cyclosporine-A-induced peroxidation. This hypothesis is supported by the finding that the purported anti-ischemic agent ebselen completely protected and rescued hippocampal cells against SNP-induced toxicity. In contrast, the hydroxyl radical scavenging properties of EGb 761 do not seem able to account for its protective effects because catalase failed to display any neuroprotective properties in this model. 

The synthesis of S-deoxy-S-(4-piperizin-l-yl)-l,4 3,6-dianhydrO L-iditol>2>nitrates 4 together with various stereoisomers as anti-ischemic agents has been described.(See also Vol. 26, Chapter 18, ref 29). The preparation of chiral auxiliaries derived from l,4 3,6-dianhydroglucitol is mentioned in Chapter 24. 

Which of the following is an anti arrhythmic agent that has relatively few electro physiologic effects on normal myocardial tissue hut suppresses the arrhythmogenic tendencies of ischemic myocardial tissues ... 

Tedisamil is a bradycardic agent because of its ability to inhibit transient outward current (7,o) in atria. Tedisamil inhibits 7,o, potassium current (7k), 7k(atp). and the protein kinase A-activated chloride channel in ventricles, as well as vascular 7k and Ca -activated 7k (7K(Ca))-As compared with atenolol, tedisamil produced a prolongation of the QTc interval (4-31 versus 8 ms) at initial values of 0.408 0.018 seconds with the PQ and QRS intervals remaining unaltered. In patients with stable angina, tedisamil (100 mg twice daily) as compared with atenolol (50 mg twice daily) generated similar hemodynamic, neurohumoral, and anti-ischemic effects." ... 

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