Anti-inflammatory steroids antibodies

The anti-inflammatory and immunosuppressive effects of glucocorticoids are largely due to the actions described above. In humans, complement activation is unaltered, but its effects are inhibited. Antibody production can be reduced by large doses of steroids, although it is unaffected by moderate doses (eg, 20 mg/d of prednisone). 

Various potential treatments have been examined experimentally (reviewed by Fricke and Poppenga, 1989). The only treatments that have shown some success are orally administered activated charcoal (an adsorbent), steroidal anti-inflammatory agents (supportive treatment), and monoclonal antibodies. Activated charcoal has been successful in multiple species, including rats and pigs, when administered prior to or shortly after experimental acute exposure to T-2 toxin (Bratich et al, 1990 Fricke and Poppenga, 1989 Poppenga et al, 1987b). Steroidal... 

Simpson A, Custovic A, Pipis S, Adisesh A, Faragher B, Woodcock A. Exhaled nitric oxide, sensitization, and exposure to allergens in patients with asthma who are not taking inhaled steroids. Am J Respir Crit Care Med 1999 160 45-49. Silknff PE, Romero F, MUgrom H, Tran ZV, Townley R, Gupta N, Rohane P, Fick R. Exhaled nitric oxide (eNO) and anti-inflammatory effects of a recombinant humanized monoclonal antibody to IgE (rhuMAb-E25) in pediatric asthma. Chest 2000 118(4) 101S. 

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