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Anti-idiotypes monoclonal, binding

Igarashi, K., Kaneda, M., Yamaji, A., Saido, T.C., Kikkawa, U., Qno, Y., Inoue, K., and Umeda, M., 1995, A novel phosphatidylserine-binding peptide motif defined by an anti-idiotypic monoclonal antibody. Localization of phosphatidylserine-specific binding sites on protein kinase C and phosphatidylserine decarboxylase. J. Biol. Chem. 270 29075-29078. [Pg.74]

A possible drawback to the use of antibodies for the treatment of toxicity is the possibility of anti-idiotypes being produced against the monoclonal antibody binding site. These antibodies could potentially mimic drug-like structural features necessary for binding to a receptor. However, antibodies do not cross the blood-brain barrier in significant amounts and studies to date have not found this to be a problem, especially when Fab fragments are used. [Pg.263]

See other pages where Anti-idiotypes monoclonal, binding is mentioned: [Pg.3]    [Pg.7]    [Pg.7]    [Pg.321]    [Pg.113]    [Pg.234]    [Pg.645]    [Pg.10]    [Pg.2318]    [Pg.104]    [Pg.21]    [Pg.343]    [Pg.81]    [Pg.482]    [Pg.114]    [Pg.149]    [Pg.150]    [Pg.330]    [Pg.330]    [Pg.24]    [Pg.201]    [Pg.1436]   
See also in sourсe #XX -- [ Pg.5 ]



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