Anti-endotoxin therapies

Rogy MA, Moldawer LL, Oldenburg HS, Thompson WA, Montegut WJ, Stackpole SA, Kumar A, Pulladino MA, Maria MN, Lowry SE, Anti-endotoxin therapy in primate bacteremia with HA-1 A and BPl. Ann Surg 1994 220 77-85. 

Non-vaccine generated anti-endotoxin reagents that bind and/or neutralize LPS, such as bactericidal permeability increasing protein (BPI), endotoxin neutralizing protein (ENP), and cationic peptide 18 conjugated to immunoglobulin G (CAP 18-IgG) have been developed for the adjunctive therapy of sepsis, but only BPI has progressed to clinical trials (Levin et al., 2000). 

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