Anthracyclinones total synthesis

Krohn K (1989) Building blocks for the total synthesis of anthracyclinones. In W Herz H Grisebach GW Kirby Ch Tamm (eds) Prog Chem Org Nat Prod Springer, Wien, New York,p 37... 

During an investigation of approaches to the total synthesis of anthracyclinone antibiotics, it has been found that carbanions derived from phenylacetonitrile add to ethyl cyclohex-2-en-l-carboxylate in a Michael fashion to give, after oxidative decyanation, the y-keto-ester (155) in good yield. 

Phthalides.—Anthracyclinone natural products continue to provide a stimulating arena for the application of phthalide chemistry in synthesis. Earlier model studies on the reaction of the dilithiated species (137) with aldehydes to give phthalides have been applied to the total synthesis of two anthracyclinone natural products (Scheme 78). ... 

Contents M.T. Davies-Coleman and D. E. A. Rivett Naturally Occurring 6-substituted 5,6-dihydro-a-pyrones -K. Krohn Building Blocks for the Total Synthesis of Anthracyclinones - M. Lounasmaa and J. Galambos Indole Alkaloid Production in Catharanthus Roseus Cell Suspension Cultures -C. E. James, L. Hough, and R. Khan Sucrose and Its Derivatives. 

Yeast-mediated key step in the total synthesis of anthracyclinones. 

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