Anthelmintics, imidazole derivative

This approach (Scheme 3) has been applied (53JCS1636) to the synthesis of 4(5)-aminoimidazole derivatives with potential antihistamine or anthelmintic properties. For example, 4(5)-amino-2-thymyloxymethylimidazole (47) was obtained from benzyl-thymyloxy acetothioimidate hydrochloride (42) (75%). Similarly, 4(5)-amino-2-phenylimidazole (48) and 4(5)-amino-2-(thiophen-3-yl)imidazole (49) were prepared (72CA19645) from benzyl-phenyl acetothioimidate hydrochloride (43) and benzyl-(thiophen-3-yl) acetothioimidate hydrochloride (44), respectively. 

ANTIBACTERIAL and ANTHELMINTIC, fenticonazole [ban. inn] (fenticonazole nitrate [usan] Lomexin ) is an (imidazole group) ANTIFUNGAL. Clinically, it can be used topically, fenticonazole nitrate fenticonazole. fentonium bromide [inn] is a quaternary amine, a MUSCARINIC CHOLINOCEPTOR ANTAGONIST, which can be used as an antispasmodic and to treat bladder irritability, fenyramidol [inn] (( )-form = phenyramidol hydrochloride [usan]) is a pyridinylaminobenzenemethanol derivative, with ANALGESIC and SKELETAL MUSCLE RELAXANT properties. 

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