Lansoprazole Antacids

Drug therapy, if necessary, may be initiated with aluminum, calcium, or magnesium antacids sucralfate or cimetidine or ranitidine. Lansoprazole, omeprazole, and metoclopramide are also options if the patient does not respond to histamine-2 receptor blockers. 

Deravirdine (Rescnptor) [Antiretroviral/NNRTI] Uses HIV Infxn Action Nonnucleoside RT inhibitor Dose 400 mg PO tid Caution [C, ] CDC recommends HIV-infected mothers not to breast-feed (transmission risk) w/ renal/hepatic impair Contra Use w/ drugs dependent on CYP3A for clearance (Table VI-8) Disp Tabs SE Fat redistribution, immune reconstitution synd, HA, fatigue, rash, T transaminases, N/V/D Interactions T Effects W/ fluoxetine T effects OF benzodiazepines, cisapride, clarithromycin, dapsone, ergotamine, indinavir, lovastatin, midazolam, nifedipine, quinidine, ritonavir, simvastatin, terfena-dine, triazolam, warfarin effects W/ antacids, barbiturates, carbamazepine, cimetidine, famotidine, lansoprazole, nizatidine, phenobarbital, phenytoin, ranitidine, rifabutin, rifampin effects OF didanosine EMS Use of benzodiazepines and CCBs should be avoided may cause a widespread rash located on upper body and arms OD May cause an extension of nl SEs symptomatic and supportive Deferasirox (Exjade) [Iron Chelator] Uses Chronic iron overload d/t transfusion in pts >2 y Action Oral iron chelator Dose Initial 20 mg/kg... 

Agents in this class are omeprazole, lansoprazole, pantoprazole and rabeprazole. Esomeprazole is the S-enantiomer of omeprazole. After ingestion of gastric acid resistant formulations they are rapidly and more or less completely absorbed. Bioavailability may be reduced if administered with food or antacids. Elimination is via metabolism in the liver and the renal excretion of inactive metabolites. The elimination half-live is very variable, however, as explained above, not related to the duration of action. 

ANTACIDS PROTON PUMP INHIBITORS -LANSOPRAZOLE Possible 1 efficacy of lansoprazole 1 absorption Separate doses by at least 1 hour... 

Maalox does not appear to alter the pharmacokinetics of omeprazole, pantoprazole or rabeprazole. Antacids may cause a slight reduction in the bioavailability of lansoprazole. This is probably not clinically relevant but can be accommodated by separating their administration by one hour. There is no interaction between sodium alginate and omeprazole. 

Delhotal-Landes B, Cournot A, VermerieN,DellatolasF, Benoit M, Flouvat B. The effect of food and antacids on lansoprazole absorption and disposition. EurJ Drug Metab Pharmacok-inet (1991), Spec No 3,315-20. 

As opposed to omeprazole and pantoprazole, concurrent intake of antacids evoked a slight reduction in bioavailability of lansoprazole [20]. The problem posed is only minor, inasmuch as PPI treatment will largely suspend the need for use of antacids. 

Gerloff J, Barth H, Mignot A, Fuchs W, Heintze K (1993) Does the proton pump inhibitor lansoprazole interact with antacids Naiinyn Schmiedebergs Arch Pharmacol 347(Suppl) R31... 

---