Flecainide Antacids

Drugs that may be affected by antacids include allopurinol, amphetamines, benzodiazepines, captopril, chloroquine, corticosteroids, dicumarol, diflunisal, digoxin, ethambutol, flecainide, fluoroquinolones, histamine H2 antagonists,... 

Uses Chronic metabolic acidosis, alkahnize urine dissolve uric acid cysteine stones Action Urinary alkahnizer Dose Adults. 2-6 tsp (10-30 mL) diluted in 1-3 oz H2O pc hs Peds. 1-3 tsp (5-15 mL) diluted in 1-3 oz H2O pc hs best after meals Caution [C, -h] Contra Al-based antacids severe renal impair or Na restricted diets Disp Liq SE Tetany, metabolic alkalosis, T GI upset avoid use of multiple 50-mL amps can cause T NaMiyperosmolality Interactions T Effects OF amphetamines, ephedrine, flecainide, pseudoephedrine, quinidine 4 effects OF barbitm ates, chlorpropamide, Li, salicylates EMS Monitor ECG for hyperkalemia (peaked T waves) OD May cause convulsions, muscle twitching, tetany, and Szs symptomatic and supportive... 

The absorption of flecainide is not significantly altered if it is taken with food or an aluminium hydroxide antacid in adults, but it may possibly be reduced by milk in infants. 

Tjandra-MagaTB, VerbesseltR, Van Hecken A, Mullie A, De SchepperPJ. Flecainide single and multiple oral dose kinetics, absolute bioavailabiUty and effect of food and antacid in man BrJCIin Pharmacol (1986) 22, 309-16. 

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