Anoxia, cyanide-induced

Cyanide also causes endogenous catecholamine release (Kanthasamyeta/., 1991 Kawada eta/., 2000 Schomiget a/., 1995 Inoue et al, 1998). Inoue et al (1998) also point out that cyanide-produced depolarization increases intracellular calcium due to the suppression of the potassium channels and activation of the voltage-dependent calcium channel. Anoxia induces suppression of the sodium pump and activates cation channels due to the decrease in ATP. A further consequence of the presence of cyanide in the tissue is inhibition of the Na+/Ca + exchanger (NCX) (Ju and Allen, 2005). NCX is important for the pacemaker currents. Metabolic inhibition of NCX reduces the firing rate of pacemaker cells. 

---