Another Point of View and Summary

In a recent account, O Neill and Posner again mentioned that high-valent iron-oxo-intermediate is important for high antimalarial activity, but this opinion is not widely accepted.  

Qinghaosu Antimalarial Coordinating Research Group. Antimalaria studies on qinghaosu. Chin. Med. J., 1979, 92(12) 811-816. 

Klayman, D. L. Qinghaosu (artemisinin), an antimalarial drug from China. Science, 1985, 228 1049-1055. 

Sharma, R.-R Some aspects of the chemistry and biological activity of artemisinin and related antimalarials. Heterocycles, 1991, 32(8) 1593-1637. 

Meshnick, S. R. Taylor, T. E. Kamchonwongpaisan, S. Artemisinin and the antimalarial endoperoxides from herbal remedy to targeted chemotherapy. Microbiological Rev., 

---