Anisomycin deacetylanisomycin

USE Anisomycin and deacetylanisomycin in the eradication of bean mildew to inhibit other pathogenic fungi in plants. 

Nitrile reduction with BH3 proceeded with cycUzation to give 8. This underwent catalytic hydrogenation in the presence of formic acid to afford the (-)-deacetylanisomycin (2). Compound 2 was subjected to a five-step sequence to produce 1 [2,26,50-52]. Thus, N-carbamate protection of 2 afforded carbamate 9, which was selectively sililated to give 10. This was acetylated to produce 11 that on treatment with TBAF followed by catalytic hydrogenation furnished (-)-anisomycin (1). 

Anisomycin (1) and deacetylanisomycin (2) were prepared from 2,3,5-tri-0-benzyl-)S-L-arabinofuranose (12) (Scheme 2) [53]. This was converted to... 

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