Animal models pituitary responses

CRH and its receptors have generated increasing interest as a target for medications. In addition to the pituitary, CRH receptors have been localized to the cortex, the nuclei of the amygdala, the LC, and regions of the hypothalamus. It has also been reported that CRH increases LC activity, and that local injection of CRH into the LC increases behavioral responses consistent with increased anxiety [105]. Furthermore, CRH antagonists have been repeatedly shown to have anxiolytic effects in animal models. 

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