Anilino nitrogen

In isomer A each ruthenium atom is axially coordinated to one pyridino nitrogen and one anilino nitrogen in isomer B one ruthenium atom is coordinated to two anylino nitrogens, whereas the other ruthenium atom is coordinated to two pyridino nitrogens. The Ru-Ru distance is the same (2.58 A) in both the derivatives. 

Synthesis routes used in the work involved condensation of l-benzyl-4-piperidone with an appropriately substituted propionamide promoted by a strong base (lithium diisopropylamide, LDI), with subsequent alkylation of anilino nitrogen (if necessary) and replacement of N-benzyl by the 2-arylethyl substituent. Direct use of the N-arylethyl-4-piperidone was also made. 

Ligand 34 acts as a tridentate ligand toward Zn(II), with the anilino nitrogen uncoordinated, but as a tetradentate hgand with Cu(II) (50). [Zn(34)] + binds dT with log K = 6.9 and the crystal structure of the l-methylth5miine adduct again shows evidence of tt-jt interaction. 

The class of compounds where the carbonyl is bonded to a nitrogen other than the anilino nitrogen is thermochemically poorly represented both in terms of the number of species that have been studied as well as in the qualitative and quantitative understanding of the results derived therefrom. The first species is A-(2-benzamidophenyl)aniline114, the enthalpy of formation for which as solid is —10 84 kJmol-1. The large error bar obscures any thermochemical conclusions we could draw. As documented in our archive, the enthalpy of formation of benzidine and its A-mono and A,A -diacetyl derivatives have all been reported in the same original paper115. From that data we deduce that the solid state disproportionation reaction 20 is exothermic by ca —81 kJmol-1. This is implausible. In a previous section we asserted that the enthalpy of formation of benzidine was substantially accurate. Does the error lie with either or both of the acetyl derivatives ... 

Vincristine is the nonproprietary name for the alkaloid originally called leurocris-tine. It is obtained from the plant Vinca rosea Linn. (Catharanthus roseus G. Don) of the family Apocynaceae(Madagascar periwinkle). Vincristine sulfate is the 1 1 sulfate salt of vincristine. The structure of vincristine differs from that of vinblastine- only by the substituent at the anilino-nitrogen in the vindoline portion of the molecule. Thus it is des-Na-methyl-Na-formyl vinblastine. It is also known by the code numbers NSC-67571 and 372313 and is abbreviated to VCR and VCR sulfate. Elucidation of the molecular structure, stereochemistry, and absolute configuration of this compound is found in the literature ... 

Fig. 19. When the f-butylaniline-terminated thread 14 is mixed in acetonitrile solution with the cyclophane CBPQT4, a pseudorotaxane is formed. Upon protonation of the anilino nitrogen atoms with trifluoroacetic acid (TFA), electrostatic repulsion leads to dissociation of the pseudorotaxane into its two constituents. Deprotonation of 14-2H leads to the pseudorotaxane being reformed...

The structural basis for potent inhibition has also been probed by preparing and testing a series of closely related analogs of 2 as IRK inhibitors (Fig. 7.2-12) [42]. Among these, replacement of the anilino nitrogen with a more native... 

The orally administered sulfonamides are well absorbed from the gastrointestinal (Gl) tract, distributed fairly widely, and excreted by the kidney. The drugs are bound to plasma protein (sulfisoxazole, 30-70%, sulfamethoxazole, 70%) and, as such, may displace other protein-bound drugs as well as bilirubin. The latter phenomenon disqualifies them for use in late term pregnancy as they can cause neonatal jaundice. Sulfonamides are partly deactivated by acetylation at N-4 and glucuronidation of the anilino nitrogen in the liver. 

X-ray crystal analysis showed some double-bond character between C-9 and the anilino nitrogen atom, in agreement with earlier demonstration of electronic transmission between the acridine and the aniline ring systems. The acridine nucleus is seen to be intercalated between the layers of bases, and the anilino ring lies in the minor groove (Baguley et al., 1981 Waring 1976). 

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