Aniline derivatives paracetamol

The nitrosation conditions of aniline and diphenylamine derivatives (paracetamol, phenacetin, mefenamic acid, and diclofenac sodium), with subsequent formation of colored products in alkaline media, were studied by Shormanov et al. [35]. Suitable procedures for quantitative determination of analytes in bulk drug substance and tablets were developed. 

Aniline derivatives (para-aminophenol derivative were, historically, also introduced in the last century. The original member used extensively in medicine was phenacetin, but this has been replaced by paracetamol (acetaminophen,... 

Paracetamol (known as acetaminophen in the USA) is N-acetyl-para-aminophenol (Figure 25.11). It has the same detoxification pathways as phenol and also carries the risk of inducing methemoglobinemia. To be on the safe side, it should not be used as an intravenous analgesic during a full-face phenol peel, so as not to saturate the detoxification pathways. Paracetamol is also an intermediate in the pathway for detoxification of aniline derivatives, before hepatic glucuronide and sulfate conjugation allow them to... 

Investigations into drugs suspected of causing cancer in humans have included aryl amine derivatives such as Paracetamol (17a)61 and phenacetin (17b). Metabolism of acetanilide (17c) yields aniline, and of 17b A-hydroxyphenacetin (18)62, in accord with views on mechanisms of toxicity as discussed in the next section. Tumor formation was induced in rats at excessively high dose levels and only under certain conditions. Drugs found to cause methemoglobinemia include antipyrine, acetanilide, sulfanilamide, sul-fapyridine, sulfathiazole, sulfonal and thional. 

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