Angiotensin II antagonists,

A closely related reaction that is currently receiving much attention is the palladium-catalysed Suzuki coupling of arylboronic acids with aryl halides (Fu and Littke, 1998). For example, this technology has recently been applied by Clariant workers for the production of o-tolyl-benzonitrile (Eqn. (13)), an intermediate to a series of so-called angiotensin-II antagonists, a new class of antihypertensive drugs (Bernhagen, 1998). 

Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo importance of drug ionization in the in vitro prediction of in vivo absorption. Eur. J. Pharm. Sci. 2000, 10, 215-224. 

Canned, R.J., Knaggs, A.R., Dawson, M.J. et al. (1995) Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite. Drug Metabolism and Disposition The Biological Fate of Chemicals, 23, 724—729. 

Safer antihypertensives include angiotensinconverting enzyme inhibitors, postsynap-tic a,-adrenergic antagonists (terazosin, doxazosin), calcium channel blockers, and angiotensin II antagonists. 

Many different drug classes have shown to cause hypotension and orthostatic reactions and drugs for cardiovascular conditions, psychoactive medicines and polypharmacy, can all have this side effect (Box 5.15). Among the most frequently used drugs in the elderly are diuretics, ACE-inhibitors, angiotensin II antagonists, calcium channel blockers and antidepressants. 

Heart medication, betablockers, ACE-inhibitors, long acting nitro derivates, calcium channel blockers, angiotensin II antagonists... 

Drugs that may affect epierenone include ACE inhibitors, angiotensin II antagonists, CYP3A4 inhibitors, NSAIDs, and St. John s wort. Drugs that may be affected by epierenone include lithium. 

Losartan potassium (1), the prototype highly selective ATi receptor antagonist (Goa and Wagstaff, 1996), was derived from the Takeda series of l-benzylimidazole-5-acetic acid derivatives, which were themselves weak angiotensin II antagonists. Losartan potassium... 

While they are often prescribed, the lower costs of codeine, ACE inhibitors, beta-blockers, thyroid hormones, calcium blockers, and benzodiazepines keep them off the list of top sales. Conversely, the higher cost of erythropoietins, antineo monoclonal antibodies, angiotensin II antagonists, antiarthritis drugs, and bisphosphonates put them on the list of top sales but not top prescriptions. 

Buhlmayer, P., Furet, P., Criscione, L., de Gasparo, M., Whitebread, S., Schmidlin, T., et al. Valsartan, a Potent, Orally Active Angiotensin II Antagonist Developed from the Structurally New Amino Acid Series. Biorg. Med. 

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