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Angiotensin-converting enzyme lead compound

Other useful biological properties found in quinolizidine derivatives include the inhibition of angiotensin-converting enzyme (ACE) by compound (343) <85JAN1003), which shares some structural features with the lead compound in this area, i.e. captopril (344), the antibacterial activity of some benzo[ij]quinolizidines (345) that belong to the quinolone group of chemotherapeutic agents... [Pg.559]

Additive pharmacodynamic effects. In the case when two or more drags exhibit similar pharmacodynamic effects it may produce an excessive manifestation of toxicity. It could be compounds whose combination may cause QT interval prolongation, leading to ventricular arrhythmia, as well as compounds that increase the concentration of potassium in blood and lead to hyperkalemia. An additive pharmacodynamic effect is also used for therapeutic purposes, so diuretics and angiotensin-converting enzyme inhibitors cause the blood pressure reduction... [Pg.356]

See other pages where Angiotensin-converting enzyme lead compound is mentioned: [Pg.262]    [Pg.163]    [Pg.130]    [Pg.1342]    [Pg.212]    [Pg.246]    [Pg.84]    [Pg.201]    [Pg.80]    [Pg.387]    [Pg.155]    [Pg.18]    [Pg.51]    [Pg.100]    [Pg.207]    [Pg.244]    [Pg.874]    [Pg.187]    [Pg.211]    [Pg.40]   
See also in sourсe #XX -- [ Pg.84 , Pg.85 ]



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