Angelica shikokiana

The roots of Angelica shikokiana are cultivated in the Oita Prefecture of Japan, and used as substitute drug for Ginseng roots and called "Yama-Ninjin". We found that the EtOAc fraction of the roots of A. shikokiana inhibited the formation of LTs B4 and C4 in human neutrophils. The active substance was isolated and shown to be 3 (/ ), 4 (/ )-3 -epoxyangeloyloxy-4 -acetoxy-3, 4 -dihydroseselin (a new compound, YN-1) "Fig. (43)". YN-1 inhibited leukotriene formation in human neutrophils dose-dependently "Fig. (44)". 

Fig. (44). Effects of YN-1 isolated from the roots of Angelica shikokiana on leukotrienes B4 and C4 formation induced by calcium ionophore A 23187 in human neutrophils.

Hata, K., M. Kozawa, K. Baba, and M. Mitsui Chemical Components of the Roots of Ligusticum hultenii Fernald and Angelica shikokiana Makino. Yakugaku Zasshi 93, 248 (1973) Chem. Abs. 78, 133334 (1973). 

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