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Androstenetriol sulfate

After the first demonstration of a direct metabolism of a steroid conjugate [androstenediol sulfate =i dehydroepiandrosterone sulfate (Baulieu et ah, 1963)], showing that a 17j8-hydroxysteroid oxidoreductase can have a sulfo conjugate as a substrate, other enzymic transformations of dehydroepiandrosterone sulfate were reported (Fig. 4). Dehydroepiandrosterone sulfate can undergo 16o -hydroxylation to 16a-hydroxy-dehydroepiandrosterone sulfate which can be further hydroxylated into androstenetriol sulfate its direct 17-hydroxylated metabolite, androstene-... [Pg.170]

Fetal brain tissues also possess very active sulfokinases for dehydro-epjandro.steronc, and after incubation of tritium dehydroepiandrosterone with minced brain tissue from a human fetus in the twelfth week of gestation, 6% of the radioactive material consisted of ester sulfates (principally dehydroejnandrostcrone and androstenetriol sulfates). Moreover, the free fraction was largely metabolized to androstenediol, androstenetriol, and 16-ketoandrostenediol (Kiiapstein et al., 1968). [Pg.194]

Fig. 18. Schematic representation of the principal transformations of the Cu and Cl steroids and their conjugates in the fetal and placental compartments. Aj-P pregnenolone P progesterone ITd-IlO-Aj-P iTa-hydroxyprcgnenolone 17a-HO-P 17a-hydroxyprogesterone DTI A dehydroepiandrosterone AND androstenedione 17/J-.D1I-DHA androstenediol-lTp DIIA-S dehydroepiandrosterone sxilfate Ida-IIO-DHA 16a-hydroxydchydrocpiandrosterone 16 -1I0-D1IA-S 16a-hydroxydehydroepi-androstcrono sulfate androstenetriol-S androstenetriol sulfate E estriol Kj-S estriol sulfate T testosterone Ej estradiol Kj-S estradiol sulfate E[ estrone E -S estione sulfate. Fig. 18. Schematic representation of the principal transformations of the Cu and Cl steroids and their conjugates in the fetal and placental compartments. Aj-P pregnenolone P progesterone ITd-IlO-Aj-P iTa-hydroxyprcgnenolone 17a-HO-P 17a-hydroxyprogesterone DTI A dehydroepiandrosterone AND androstenedione 17/J-.D1I-DHA androstenediol-lTp DIIA-S dehydroepiandrosterone sxilfate Ida-IIO-DHA 16a-hydroxydchydrocpiandrosterone 16 -1I0-D1IA-S 16a-hydroxydehydroepi-androstcrono sulfate androstenetriol-S androstenetriol sulfate E estriol Kj-S estriol sulfate T testosterone Ej estradiol Kj-S estradiol sulfate E[ estrone E -S estione sulfate.
The major group of steroids found in cord blood has the 3jS-hydroxy-A" configuration. The steroids present are largely sulfate esters (C12, C13, C16, E2, E4, M12, S5, S12, S20). In addition to those listed in Table 4 and shown on the thin-layer chromatogram in Fig. 5, the following have been characterized or tentatively identified androstenetriol (S12) 3j0,17a,2Oa-trihydroxypregn-5-ene (E4) 3/8,20a-dihydroxypregn-5-ene... [Pg.170]


See other pages where Androstenetriol sulfate is mentioned: [Pg.170]    [Pg.172]    [Pg.178]    [Pg.157]    [Pg.194]    [Pg.170]    [Pg.172]    [Pg.178]    [Pg.157]    [Pg.194]    [Pg.196]   


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Androstenetriol

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