Androgens imprinting

CYP enzyme Testosterone hydroxylase activities Androgenic imprinting s Thyroid hormone ... 

Shimada, M., N. Murayama, Y. Yamazoe, T. Kamataki, and R. Kato (1987). Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations. Jpn. J. Pharmacol. 45, 467-478. 

Jansson, J.O. and L.A. Frohman (1987). Inhibitory effect of the ovaries on neonatal androgen imprinting of growth hormone secretion in female rats. Endocrinology 121, 1417-1423. 

To establish the kinetics of this imprinting process, male animals were castrated at either 2, 4, 7, 10 or 14 days of age. All groups received one week of androgen replacement therapy before sac-... 

In conclusion, the sexual dimorphism observed for rat liver xanthine oxidase activity in the male appears to result from the effect of androgen exposure in the neonatal period. This imprinting phenomenon is complete by four days of age and does not require an intact pituitary in the presence of androgen replacement for full expression of adult sexual dimorphism. The adult female is unresponsive to androgen therapy and hypophysectomy. In the female, this unresponsiveness may result because of the lack of androgen exposure in the neonatal period. 

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